How Weed Makes Us Feel Happy? Understanding Anandamide, the Cannabis Bliss Molecule

How Weed Makes Us Feel Happy?

Anadamide or better known as Cannabis bliss enzyme, also known as AEA, is said to have unique properties offering mystery of the joy cannabis gives its users.

Cannabinoids are an exciting group of compounds. Over the years, cannabis inclined researchers or scientists have made several discoveries concerning cannabis plants, their cannabinoid and terpene profiles, as well as their unique relationship with the human endocannabinoid system (ECS).

It might interest you that the human body natural praduces cannabinoids, a type of anandamides. As you read on, you will be exposed to a whole new realm of anandamides and how they react with other important cannabinoids like THC and CBD, and they are referred to as pleasure particles.

Unwinding Anandamide

Anandamide is in practical sense a primary endogenous cannabinoid produced inside the human body. This type of cannabinoids are not as well-known as other plant derived phytochemicals, still they bind well with each other.

In literal terms anandamide means ‘the bliss particle’. So many people assumed that this compound is informally called the happiness particle whereas it’s just the literal meaning of the name. Anand means enjoying or bliss, while amide is used to mention the molecules chemical formula.

Anandamide has an unique traits and activities that helps the ECS have a beneficial relationship with plant-derived cannabis plants. Until 1900’s it was not discovered, while other phytochemicals like THC, CBD where found by the researchers. Subsequently, science journals suggested that phytocannabinoids could easily combine to our receptors in the human body to highlight their impacts. Between 1990 and 1995, Dr. Rapheal Mecholam and his research team reported successfully isolating anandamide from the human brain.

As mentioned earlier, anandamide is naturally produced in the human body in low quantities. The production process is distributed through different molecular pathways using multiple enzymes. Anandamide has a relatively short half-life that starts with N-arachidonoyl phosphatidylethanolamine (NAPE), the membrane precursor. When anandamide is released into the body, it dissipates quickly.

The Significance and Function of Anandamide

Mainly two compounds CB1 and CB2 receptors are responsible of developing the endocannabinoid system (ECS). Both the receptors interact with other factors to ensure the body’s homeostatic state is maintained.

The research team consisting of Lumir Hanus, William Devane and Mechoulam observe that the bliss molecule behaves like THC. Both compounds have a highly bindable reaction with cannabinoid receptors. Anandamide and THC are partial agonists of CB1 and CB2. They are capable of inducing effects on the CNS and the immune system. Still THC has a stronger, more innate relationship with the CB1 receptor. For a more extended period, THC catalyzes multiple chemical effects. In contrast, anandamide is fragile, which is another reason it cannot induce a significant psychoactive effect. It is instead responsible for inducing feelings of pleasure, rewards, inspiration, or motivation.

Its location is the brain is mainly in areas that are relevant to memory, feeding, learning, and movement. Scientists say that anandamide allows humans to make or break neutral connections that foster memory and learning. 

Relating Cannabis and anandamide

Anandamide and cannabis have a special, multifaceted relationship. Each cannabinoid in the cannabis plant has a different effect on the bliss molecule. Scientists would have preferred more information on the results of THC and CBD on the AEA molecule.


THC and anandamide have similar profiles. They are both partial agonists of the CB1 receptor, and they have relatable chemical statures.   When the body breaks down THC, it proceeds to hijack the CB1 receptors, causing a more profound dramatic response. Niche Hemp Co. is set to introduce a range of organic skincare products for radiant and well-nourished skin. To get your Niche Hemp skincare range visit and bring home the goodness of hemp.  

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